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Allelic variation

Allelic variation. An allele (short for allelomorph) is a variant of a gene were the DNA sequence differs between two or more variants. Allelic variation describes the presence or number of different allele forms at a particular locus (locus or loci = place) on a chromosome (allelic variation is sometimes used more loosely to describe the overall. Summary: This review represents current knowledge about allelic variation in gene expression and its increasingly important role in understanding the genotype-phenotype relation. Characterization of these allelic variations may open largely uncharted territory in genomics for biomedical researchers and may eventually lead to the discovery of the causative genes of common hereditary diseases and their mechanism of action

Allelic variation - Warwic

The allelic variation has been confirmed by real-time quantitative PCR experiments. Some of these 170 genes are known to be imprinted, such as SNRPN, IPW, HTR2A, and PEG3. Most of the differentially expressed genes are not in known imprinting domains but instead are distributed throughout the genome Allelic variation describes the presence or number of different allele forms at a particular locus (locus or loci = place) on a chromosome (allelic variation is sometimes used more loosely to describe the overall diversity present) Allelic Variation of MYB10 Is the Major Force Controlling Natural Variation in Skin and Flesh Color in Strawberry ( Fragaria spp.) Fruit Plant Cell . 2020 Dec;32(12):3723-3749. doi: 10.1105/tpc.20.00474 Noticeably, the reported allelic variation of FimH causes a biologically relevant shift in adhesion that occurs both in broad-host range Salmonella, such as Typhimurium and Newport, and in host.

Allelic variations in gene expressio

The allelic variation of glutenin subunits can provide a more direct, reliable and efficient tool for the conservation and management of germplasm. In this study, the compositions and allelic variation of low molecular weight glutenin subunit (LMW-GS) in 149 worldwide-originated durum wheat were analyzed using MALDI-TOF-MS Allelic Variation of MYB10 Is the Major Force Controlling Natural Variation in Skin and Flesh Color in Strawberry (Fragaria spp.) Frui Allelic variation at a locus is measurable as the number of alleles (polymorphism) present, or the proportion of heterozygotes in the population. A null allele is a gene variant that lacks the gene's normal function because it either is not expressed, or the expressed protein is inactive Allelic variation in 5-HTTLPR and the effects of citalopram on the emotional neural network Published online by Cambridge University Press: 02 January 2018 Yina Ma Allelic variation at Psy1-A1 and association with yellow pigment in durum wheat grain. A. Singh 1, S. Reimer 1, C. J. Pozniak 1, F. R. Clarke 2, J. M. Clarke 2, R. E. Knox 2 & A. K. Singh 2 Theoretical and Applied Genetics volume 118, pages 1539-1548 (2009)Cite this articl

If the variation in expression of a particular transcript is a result of genuine cis modulation, the expression of B and D alleles will be significantly different in F 1 hybrids. If the variation in expression across BXD strains is a result of trans modulation or is simply an artifact, no difference in allelic expression will be observed in. where the baseline editing levels common to the two alleles were represented by the fixed effect term α ik; the parameter δ i captures the difference between the logit transformed editing levels between the two alleles; and σ i1 2 and σ i2 2 are the variances of allele 1 or allele 2 across multiple individuals (or replicates). The Benjamini-Hochberg procedure was used to control the FDR at 10% Full size image. We have identified functionally important allelic variation at a gene responsible for pheromone-race difference in a moth species. Unravelling the genetic changes that cause. Although, there are several instances of allelic variation in epigenetic modifications (e.g. differential methylation) underlying variation for agronomic traits (Shindo et al., 2006; Shen et al., 2014; Fang et al., 2016), we present evidence of allelic variation associated with the Fie1 as a contributing factor in grain size and quality determination in rice under high temperatures These genotypes were further characterized for seed dormancy/germination behavior in five other test conditions, including seed coat removal, gibberellins, and an abscisic acid biosynthesis inhibitor. The role of the Ler/Cvi allelic variation in affecting dormancy is discussed in the context of current knowledge of Arabidopsis germination

Allelic variation in gene expression is common in the

In this study, we characterized the allelic variation at the VRN-1 promoter region in polyploid wheat. The Vrn-A1a allele has a duplication including the promoter region. Each copy has similar foldback elements inserted at the same location and is flanked by identical host direct duplications (HDD) Natural allelic variation of DNR1 is associated with variation in plant and grain morphology and grain yield performance. (A) DNA polymorphisms in the promoter region of DNR1 . (B-E) Violin plots for plant height (B), number of tillers per plant (C), number of grains per panicle (D), and grain yield (E) of rice varieties carrying different DNR1 promoter haplotypes (Haplotype A, Haplotype B-TEJ, or Haplotype B-TRJ)

Allelic variation associated with CNV at Vrn-A1 had a significant effect on heading date in this germplasm . Low copy number at Vrn-A1 is associated with earlier flowering following a short vernalization period . Copy number variation at Vrn-A1 was inferred by SNPs on exons four and seven These results provide evidence that variation in one transcriptional regulator has generated an allelic series strongly associated with fruit color variation in cultivated grapevine. These findings provide information about the evolution of grapes since domestication and have direct implications for the regulation of fruit and wine quality of this important crop plant The predominance of the peak near ACD6 in the genome-wide scan demonstrates that allelic variation at this locus is the major determinant of global variation for this trait

Allelic variation - SlideShar

Allelic variation in gene expression in several of the histocompatibility complex (MHC) genes was previously reported , . There are also clusters of allelic variation in 11q13-q23 and 20q11-q12 (Table 2 and Supplemental figure and tables). Download : Download full-size image; Fig. 2. Mapping of SNPs with allelic variation An understanding of allelic variation present in maize provides an opportunity to speculate on mechanisms that might lead to heterosis. Variation for the presence of genes, the presence of novel beneficial alleles, and modified levels of gene expression in hybrids may all contribute to the heterotic phenotypes

Allelic Variation of MYB10 Is the Major Force Controlling

Allelic size variation of these loci resulted exclusively from differences in the structures of repeat motifs, which involved interruptions or occurrences of new motif repeats in addition to varying number of AG/CT repeats Although most of the work on interpreting human allelic variation is confined to the domain of statistical and population genetics, a growing body of literature is devoted to the analysis of coding genetic variation from the perspective of protein function, structure and evolution Allelic variation in human gene expression. Yan H(1), Yuan W, Velculescu VE, Vogelstein B, Kinzler KW. Author information: (1)Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA Because allelic expression biases are only produced (and detectable) in heterozygotes, Hybrid Swarm populations facilitate the study of regulatory genetic variation (i.e.. The importance of this allelic expression variation in determining phenotypic diversity has been reviewed recently by Knight (2004). Virtually nothing is known regarding such allelic variation of gene expression at the transcript level in maize. The high level of allelic variants in maize could lead to a high level of allelic expression variation

The major physiological determinants of wheat (Triticum aestivum L.) phenology in a given area are a response to vernalization temperature and day length, which are at least in part, regulated by the allelic variation at the vernalization (VRN) and photoperiod (PPD) loci, respectively. Characterization of the existing genetic variation for plant phenology in winter wheat can assist breeding. Allelic variation of the MMP3 promoter affects transcription activity through the transcription factor C-MYB in human brain arteriovenous malformations. Huai C(1), Song J, Ma Z, Qin X, Li P, Chen H, Zhao F, Lu D, Song D, Mao Y, Song X, Zhao Y

Allelic variation contributes to bacterial host

To assess whether allelic variation in CYP6P9a and CYP6P9b was the most important factor conferring pyrethroid resistance even more than gene over-expression, a resistant (Malawi) and a susceptible (FANG) alleles for each gene were independently expressed in D. melanogaster, using the GAL4-UAS system. The hypothesis being that if sequence. 3. Non Allelic Gene Interactions: Simple Interaction (9:3:3:1): In this case, two non-alleiic gene pairs affect the same character. The dominant allele of each of the two factors produces separate phenotypes when they are alone. When both the dominant alleles are present together, they produce a dis­tinct new phenotype Allelic length variation has been documented in the large heterogeneous telomeres of mice 21,22. Unlike in mouse cells, however, telomere length is the key determinant of replicative lifespan in.

Therefore, both new (Lake Malawi) and ancient (Lake Victoria) allelic variation at the same locus fueled rapid and convergent phenotypic evolution. standing genetic variation, cichlid fishes, convergent evolution, color patterns, evolutionary genomics, adaptive radiations Allelic variation at the vernalization genes Vrn-A1, Vrn-B1, Vrn-D1 and Vrn-B3 in Chinese common wheat cultivars and their association with growth habit. Crop Sci . 48, 458-470. doi: 10.2135/cropsci2007.06.035 Allelic variation in floral quantitative traits, including the elements of flowers and fruits, is caused by extremely complex regulatory processes. In the genetic improvement of flare tree peony. What are variants? In the field of genetic variation, the term variant is used to refer to a specific region of the genome which differs between two genomes.. What are alleles? Different versions of the same variant are called alleles.For example, a SNP may have two alternative bases, or alleles, C and T 4.. When working with genome scale data the term reference allele refers to the base that.

Allelic variation of polyphenol oxidase (PPO) genes located on chromosomes 2A and 2D and development of functional markers for the PPO genes in common wheat. X. Y. He 1, Z. H. He 1,2, L. P. Zhang 3, D. J. Sun 4, C. F. Morris 5, E. P. Fuerst 6 & X. C. Xia 1 Theoretical and Applied Genetics volume 115, pages 47-58 (2007)Cite this articl Allelic Variation of MYB10 is the Majo r Fo rce Cont roll ing Natu ral Vari atio n of Skin and Flesh Col or in Straw berry ( Fragaria spp.) fru it Cristina Castillejo 1,2 , Veronika Waurich 3,4.

Allelic variation of low molecular weight glutenin

  1. ation to create a framework beyond lineage definition. The longitudinal nature of this created a repeated measures paradigm with the GENI.
  2. Allelic Variation at the Vernalization Response (Vrn-1) and Photoperiod Sensitivity (Ppd-1) Genes and Their Association With the Development of Durum Wheat Landraces and Modern Cultivars. Conxita Royo 1*, Susanne Dreisigacker 2, Jose Miguel Soriano 1, Marta S. Lopes 1, Karim Ammar 2 and Dolors Villegas 1
  3. Genetic variation is the difference in DNA among individuals or the differences between populations. There are multiple sources of genetic variation, including mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, but other mechanisms such as sexual reproduction and genetic drift contribute to it as well
  4. Population and allelic variation of A-to-I RNA editing in human transcriptomes. Eddie Park 1, Jiguang Guo 2, Shihao Shen 1, Levon Demirdjian 3, Ying Nian Wu 3, Lan Lin 1 & Yi Xing 1 Genome Biology volume 18, Article number: 143 (2017) Cite this articl

We found that variation of (E)-β-ocimene and (E)-α-bergamotene contributed to the correlated changes in HIPVs and floral volatiles among N. attenuata natural accessions. Intraspecific variations of ( E )-β-ocimene and ( E )-α-bergamotene emissions resulted from allelic variation of two genetically co-localized terpene synthase genes. Allelic expression variation of nonimprinted autosomal genes has recently been uncovered in mouse hybrids and humans. The allelic expression variation is attributed to differences in noncoding DNA.

  1. Allelic variation is common among all eukaryotic and prokaryotic organisms, as well as viruses, and is a well-recognized source of individual differences in genetic composition and behavior. Allelic variation in human genes that results in structural variation in encoded proteins can have a profound effect on phenotype and overall fitness
  2. The allelic variation at the Glu-D3 was limited to the presence of two alleles Glu-D3a and Glu-D3b. The allele Glu-D3b was the major allele in Moroccan bread wheat (95%) and generally reported to be associated with good quality (Lerner et al. 2009)
  3. Knockout mice cannot address the issue of allelic variation, and thus there is a possibility that Ticam2 −/− mice phenocopy Hrs5, and another gene or genes are responsible for the SARS-CoV phenotypes that map to chromosome 18. Use of CRISPR/Cas9 genome editing approaches to swap alleles, rather than ablate genes, and directly testing.
Neanderthal DNA Contributes to Human Gene Expression

Allele - Wikipedi

Definitions: DNA, genes, chromosomes and alleles, base sequence. Why chromosomes exist as pairs Although these revisions may require updating on, e.g., test reports, standardized mapping of allelic variation is a prerequisite to facilitating genomic data analysis, automated pipelines, and standardized reporting. In addition to being a searchable database, PharmVar will also offer a number of graphical display functions, including. Indeed, if the NP variant is more effective in promoting carotenoids in etioplasts, this allelic variant could be valuable in selecting plants that are more resilient to climate change. In summary, further studies on the effect of sequence variation are key to metabolic engineering of carotenoids

Allelic variation in 5-HTTLPR and the effects of

  1. Haplotype variation in other regions of the VRN-A1 gene. In a previous study, we characterized the allelic variation of the VRN-A1 gene within an 810-bp region between intron 4 and exon 8 in a set of common wheat lines including 40 spring and 37 winter lines (Sherman et al. 2004)
  2. A decrease in the allelic richness could lead to a reduction in the population's potential to adapt to future environmental changes, since this diversity is the raw material for evolution by natural selection . While not all variation is related to the adaptive potential, clearly no standing variation exists if no allelic richness exists
  3. allelic variation [remove] 2; food choices 2; acid tolerance 1; alleles 1; biochemical pathways.
  4. Allelic variation in TraesCS5D01G044600 between CH1357 and TC29. We amplified the complete sequence of TraesCS5D01G044600 from both CH1357 and TC29 using a single PCR. The gene-specific primers PmCH1357-F2 and PmCH1357-R1 were designed based on the CS genomic sequence
  5. Lessons from multi-allelic variation and clonal hematopoiesis •Interesting sources of unexplained heritability, but what was essential in studying them were SNP data from vast numbers of people and new ways to think about old data types • Imputation and IBD analyses become every more enabling and powerful a
Fundamental Concepts in Genome Sequencing and GenomeEarly human settlements in contrasting environments: HLA

Only a small fraction of the DMRs displayed non-additive DNA methylation variation, which, however, showed no overall correlation relationship with gene expression variation. In contrast, most of the allelic-specific expression (ASE) genes in the hybrid were associated with DNA methylation, and the ASE negatively associated with allelic. Multiple Alleles . While most genes exist in two allele forms, some have multiple alleles for a trait. A common example of this in humans is ABO blood type. Human blood type is determined by the presence or absence of certain identifiers, called antigens, on the surface of red blood cells.Individuals with blood type A have A antigens on blood cell surfaces, those with type B have B antigens. Genetic Allelic Variation in the p53 DNA Repair Pathway Constitute a Risk Factor for Long-Term Survival in Hematopoietic Stem Cell Transplantation Author links open overlay panel Stige. Bojesen 1, * Mari Malkki 2, * Ted Gooley 3, * Lue Ping Zhao 3, * Annamalai Selvakumar 4, * Stephen R Spellman MS 5, * Effie W Petersdorf MD 6, * John A. Hansen.

The Lancet Association between clozapine response and allelic variation in 5-HT2A receptor gene M.J. Arranz PhD * a * Correspondence to: Dr Maria J Arranz D.A. Collier PhD a M. Sodhi MRPharmS a D. Ball MRCPsych a G.W. Roberts PhD a P. Sham MRCPsych a R. Kerwin MRCPsych a J. Price PhD b G.W. Roberts b a Sections of Molecular Genetics and Neuropsychopharmacology, Institute of Psychiatry, London. The allelic variation suggested that there is extensive genomic diversity amongC. neoformans clinical isolates from one geographic area. Thevarious alleles are potentially useful markers in the. Allelic variation of TaGS3-7A in Chinese mini-core collection based on Kompetitive allele-specific PCR (KASP) marker designed for the SNP at position 1907 (A/G). Table S2. Allelic variation of TaGS3-7A in main wheat production areas (Hebei, Shandong, Shaanxi, Henan and Sichuan) in China based on Kompetitive allele-specific PCR (KASP) marker. Get Notes Here - https://payments.pabbly.com/subscribe/5e2954ad14a2e43f1110d5ef/notesClass: 12thSubject: BiologyChapter: Principles of Inheritance and Variat.. Yet examples are lacking from autopolyploid systems, where a large pool of standing variation is expected by theory due to larger effective population size and polysomic masking of allelic.

Aim 1: To characterize allelic variation of known and predicted intestinal colonization factors from 1,000well documented S. enterica isolates from our Salmonella Reference Center collection of~ 50,000 strains, using a recently developed targeted MPS strategy. Correlations will beevaluated between (a) strains carrying defined combinations of. Information recall - accessing the knowledge you've gained about allelic variation Additional Learning. More on the subject of alleles can be found in the lesson on Allelic Variation. In this. Finally, allelic variation in the GNAT3, SLC2A2, SLC2A4, TAS1R1 and TAS1R2 genes was associated with caries status, whereas TT, PT and food preferences were not. It was concluded that variations in taste receptor, glucose transporter and gustducin encoding genes are related to taste perception, food preference and intake as well as the sugar. Primary source of allelic variation is recombination. Recombination is the natural process of breaking and rejoining DNA strands to produce new combinations of genes and, thus, generate genetic variation. This is the phenomenon that occurs during meiosis I

As such, the observed allelic variation in protein-coding genes caused by TE insertion in wild emmer wheat might impact the expression of those genes. Note that most of the genes that were found to harbor polymorphic MITE insertions were not studied before in wheat. In addition, we found that the genes are highly conserved (over 99% similarity. Variation | Genetics | Biology | FuseSchoolLook at these baby animals. You will have immediately observed how cute and fluffy they are but you willalso have..

Biodiversity and genetic variation - WUR

No allelic variation in genes with high gliadin homology in patients with celiac disease and type 1 diabete

Allelic variation at Psy1-A1 and association with yellow

  1. Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. Specifically, it is the fraction of all chromosomes in the population that carry that allele. Microevolution is the change in allele frequencies that occurs over time within a population
  2. Allelic Variation of OmpA. Consistent with the shifting OmpA spots in the proteome analysis, we found that there is substantial variation in the translated sequences (Figure 4, Table 3A). Specifically, polymorphisms were observed in each of the four extracellular loops, within three of the eight transmembrane segments, within the proline-rich.
  3. o acid sequences of two alleles of TSPG and show that they differ by an a
  4. Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume Han Kyu Lee, 1 Sehoon Keum, 1 Huaxin Sheng, 2 David S. Warner, 2 Donald C. Lo, 3 and Douglas A. Marchuk 1 1 Department of Molecular Genetics and Microbiology

Detection, Validation, and Downstream Analysis of Allelic

Allelic variation and distribution of the major maturity genes (E1, E2, E3 and E4) has been determined in 445 genotypes from soybean collections of NA ancestral lines, Chinese germplasm, European varieties, and NS varieties and breeding lines. The study showed that allelic combinations of E1-E4 genes significantly determined the adaptation of. 1 Structural Variation CYP2D6 06-11-2019_v1.6 Alleles with CYP2D7 conversions: Many CYP2D6 allelic variants carry a small region that is derived from CYP2D7 (Figure 3).These 'embedded' regions are typically referred to as CYP2D7 conversions. Note that non-duplicated alleles with embedded CYP2D7-derived conversions have a REP6 3' end. Also noteworthy is CYP2D6*36 which contains an. Allelic sequences of this extremely polymorphic locus have been derived from whole genome short read sequence data by mapping to a reference library followed by assembly of mapped reads. The catalogue of sequence variation has been greatly expanded, so that there are now more than 500 different msp1 block 2 allelic sequences described

Population and allelic variation of A-to-I RNA editing in

  1. Classification of STR allelic variation using massively parallel sequencing and assessment of flanking region power. over 700 times lower than with length-based alleles alone. Including the sequence variation within the flanking regions only resulted in a combined RMP that was a further 4 times lower. Citation. Forensic Science.
  2. Effect of Glu-B3 Allelic Variation on Sodium Dodecyl Sulfate Sedimentation Volume in Common Wheat (Triticum aestivum L.) Hongqi Si , 1 , 2 , 3 Manli Zhao , 2 Fuxia He , 2 and Chuanxi Ma 1 , 2 , 3 1 School of Agronomy, Anhui Agricultural University, Hefei 230036, Chin
  3. Background Characterization of genome-wide patterns of allelic variation and linkage disequilibrium can be used to detect reliable phenotype-genotype associations and signatures of molecular selection. However, the use of Sesamum indicum germplasm for breeding is limited by the lack of polymorphism data. Results Here we describe the massively parallel resequencing of 29 sesame strains from.
  4. e D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11) AU - Taylor, Jas
  5. D receptor gene, and lifestyle factors in a population-based association study. METHODS Random population-based sample of 110 men and 172 women over 60 years of age participating in the Dubbo Osteoporosis Epidemiology Study who had spinal radiographs (performed according to a standardised.
  6. degree of allelic variation in surface-exposed molecules, including adhesins that promote host colonization. Subsequent multinomial logistic regression, MultiPhen and Random Forest analyses of known/suspected adhesins from 580 independent Typhimurium isolates identifies distinct host-specific nsSNP signatures
  7. Human allelic variation: perspective from protein function, structure, and evolutio

Allelic variation in a fatty-acyl reductase gene causes

An individual inherits two alleles for each gene, one from each parent. If the two alleles are the same, the individual is homozygous for that gene. If the alleles are different, the individual is heterozygous. Though the term allele was originally used to describe variation among genes, it now also refers to variation among non-coding DNA. Learn Mendel's Law of Inheritance & Allelic Interactions from Class 12 Biology Chapter 5 Principles of Inheritance and Variation for NEET 2021 along with a l.. Sequence Similarity and Allelic Variation of the DHN Gene. Based on the morpho-physiological data, a subset of genotypes were selected for the sequence similarity and identification of allelic variation through sequencing. The DHN gene sequence was partially amplified through the genomic primer (Roorkiwal and Sharma, 2012) Allelic variation in Salmonella: an underappreciated driver of adaptation and virulence. Front Microbiol 4:419). Most importantly, as a proof of concept we demonstrated the use of our stepwise approach, that was published in a high impact scientific journal (Yue M, et al. 2015. Allelic variation contributes to bacterial host specificity

Allelic variation in rice Fertilization Independent

A virus-induced gene silencing strategy was used to knock-down cPGK2 expression, resulting in drastically reduced PPV accumulation. These results indicate that rpv1 resistance to PPV carried by the Cvi-1 and Col-0 accessions is linked to allelic variations at the Arabidopsis cPGK2 locus, leading to incomplete, compatible interaction with the virus Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice: Abstract: Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory. Allelic variation is widespread in different strains and in different individuals in a population. The frequency of variation between common laboratory strains of yeast is estimated to be as high as 1% ().Two Saccharomyces cerevisiae strains, S96 (MATa ho lys5) and YJM789 (MATα ho::hisG lys2 cyh), a clinical isolate from a human lung, were chosen for study () Allelic variation in RGS4 might impact brain structure in a number of ways, because it is dynamically expressed throughout the brain during development and is thought to influence neuronal differentiation through its regulation by the paired-like homeodomain protein Phox2b (Grillet et al., 2003). In addition, RGS4 regulates signaling at. Helicobacter pylori strains show both geographic and disease-associated allelic variation. We investigated the diversity present in two genes, babA and babB , which are members of a paralogous family of outer membrane proteins. Eleven family members within a single H. pylori strain, predicted to encode proteins with substantial N- and C-terminal similarity to each other, were classified as.

Darwin theorized that it was the process of naturalFrontiers | Locus heterogeneity disease genes encodeMendelian Genetics - Biology 4631 with Bucheli at SamSoftGenetics - Software PowerTools for Genetic Analysis

Helicobacter pylori strains show both geographic and disease-associated allelic variation. We investigated the diversity present in two genes, babA and babB, which are members of a paralogous family of outer membrane proteins. Eleven family members within a single H. pylori strain, predicted to encode proteins with substantial N- and C-terminal similarity to each other, were classified as babA. Fig. 1 Cis-regulatory variation, allelic expression, and ANEVA. (A to D) Examples of allelic expression across individuals (dots) for four genes with a single aeSNP each. In (A), similar haplotype expression levels for the gene indicate little cis-regulatory variation. In (B) to (D), there is relatively more variation Define allelic. allelic synonyms, allelic pronunciation, allelic translation, English dictionary definition of allelic. n. Any of the alternative forms of a gene or other homologous DNA sequence. Allelic variation of polymorphic vaccine candidates merozoite surface protein-2 in Plasmodium falciparum isolates from South-East of Iran